27655
Sigma
Colistin sodium methanesulfonate
BioChemika, from Bacillus colistinus
| Synonym: | Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate |
| CAS Number: | 8068-28-8 |
| Linear Formula: | C58H115N16Na5O28S5 |
| Molecular Weight: | 1759.90 |
| EC Number: | 232-516-9 |
| MDL number: | MFCD00130824 |
| PubChem Substance ID: | 24856709 |
Description
| Biochem/physiol Actions | Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. |
| Other Notes | Cyclopolypeptide antibiotic. Endotoxin-binding capacity1 |
Properties
| biological source | from Bacillus colistinus |
| product line | BioChemika |
| ign. residue | ~20% |
| loss | ≤1.5% loss on drying |
| pH | 6-8 (10 mg/mL in H2O) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 2 |
| RTECS | GH1650000 |
References
| Cited Reference | 1. M.J. Rogers, J. Cohen Infection (Munich) 14, 79, (1986) |
| Merck | Merck 13,2503 |
